Groups from both sides of the Irish border and the US are involved in the agreement.
A new initiative has been launched to promote cross-border and transatlantic innovation and trade.
A memorandum of understanding will be signed this afternoon by the Louth and Meath Education and Training Board (LMETB), the Portview Trade Centre in Belfast and the Ireland Institute of Pittsburgh.
The Ireland Institute of Pittsburgh aims to promote the mutual understanding of Catholic and Protestant traditions in Northern Ireland.
Catalyst Connection, a training service provider based in Pittsburgh, will also sign the agreement.
The groups involved hope the initiative will advance manufacturing skills across the island of Ireland and the US and result in greater economic opportunities.
Congressmen Mike Doyle and Mike Kelly, both US Representatives for Pennsylvania, will attend a ceremony in Dundalk this afternoon to mark the signing of the agreement.
LMETB Chief Executive Martin O’Brien says the new Advanced Manufacturing Technology Centre of Excellence in Dundalk will play a central role in the initiative: